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This continued for 40 years and only ended in 1972 after the experiment started getting public attention and press

Medications for nicotine replacement include bupropion, nortriptyline, clonidine, and varenicline

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you can also get individual chapter wise section or region wise report version like North America, Europe or Asia

Cochranes living systematic review has also found evidence that nicotine e-cigarettes can help people stop smoking, while noting that longer-term safety and newer products still require continued evidence review (Lindson et al., 2025